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Today we will like to discuss with you some of the new and latest approaches in assisted reproductive technology to improve the outcome of IVF treatment in both men and women infertility. The treatment of infertility has become more individualized for each patient and needs to be customized. The treatment is not the same for all patients, as it is not one size fits all. It is upto the discretion of the doctor, based on his experience and expertise to customize the treatment to optimize the results.
The customized approach to increase the success rate can be divided broadly in to following categories.
Platelet Rich Plasma (PRP) instillation in the uterus can help to increase the thickness of endometrium to improve embryo implantation rate.
Both systematic administration and local perfusion of G-CSF play a beneficial role in ART treatment, especially for recurrent implantation failure (RIF).
Several studies had seemed to find some benefit to hysteroscopy after an IVF cycle had failed. Some clinics now routinely perform the procedure on every woman before beginning IVF
It is a method of freezing, eggs, embryos and sperms at very low temperature suddenly, transforming tissues to a glass like state. This preserves the morphological and physiological state of the cells for storage. The gametes and embryo can be stored in liquid nitrogen for use at other opportune time.
In some women during IVF there is repeated failure of implantation, when everything else seems alright. This is due to the implantation window. The implantation window is defined as that period when the uterus is receptive for implantation for the free-lying blastocyst. This period of receptivity is short and results from the programmed sequence of hormonal communication between blastocyst and endometrium. Now there is a test by which window of implantation can be determined in such cases. The procedure is called Personalized embryo transfer (PET).
Another technique which helps to improve IVF results is embryo culture. Normally, most embryo are transferred on day three after fertilization. Now , new culture media allow us to keep embryos alive upto day 5 or 6. This allows only healthy, hardy embryos to survive up to day 5-6. Embryos transferred late improves the success rate of IVF.