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Platelet Rich Plasma (PRP) has become quite popular as an non surgical alternative to a very large number of medical conditions. It is widely in use for healing surgical wounds, orthopedic and sports medicine for promoting natural healing. It helps to heal musculoskeletal diseases such as tendonitis, arthritis, torn ligaments and sprains. PRP is also used extensively in sports injuries for pain relief.
PRP used in various therapies is derived from patient’s own blood (autologous) by centrifugation to remove red blood cells (RBC). The remaining plasma is re-centrifuged to concentrate Platelets (5-10times the normal concentration), for treatment. The growth factors, in the platelets promote natural healing. The platelets not only promote healing but also attracts stem cells to the site of injury and stimulate endogenous tissue stem cells to replace damaged cells in each tissue. Here we will like to discuss the use of PRP in various gynecological disorders. A survey of literature shows the plausible use of PRP in following gynecological disorders.
PRP is used in gynecology for the treatment of various conditions due to its healing property and initiation of anti inflammatory reactions. The healing process begins with clot formation, release of growth factors, to achieve wound healing, attracting stem cells to initiate regeneration.
Repeated implantation failure (RIF) is defined as failure to achieve pregnancy after several embryo transfers in IVF cycles. Several factors may be involved in the implantation process, including embryo quality, endometrial receptivity, and immunological factors.
Several methods have been suggested to overcome implantation failure. Since, intrauterine infusion of PRP helps improve thickness and receptivity of the endometrium, PRP has been also used to improve pregnancy rates in RIF patients. The RIF patients younger than 40 years with BMI below 30 kg/m2 treated with intra uterine infusion of PRP, a significant number became pregnant. This study confirms that PRP is effective in improving pregnancy rates in RIF patients.
PRP is being used with great success in many dermatological and autoimmune conditions nonresponsive to corticosteroids, such as lichen sclerosus (LS) and eczema. LS also causes progressive pruritus, dyspareunia, and genital bleeding. It has a considerable impact on the quality of life of affected patients. Nearly in all patients treated with PRP show clinical improvements in the size of their lesions, and in some cases the lesion completely disappeared.
The application of autologous PRP twice a week shows promise for the treatment of cervical ectopy in symptomatic women, as it results in a shorter tissue healing time and milder adverse effects than routine laser treatment.
Application of Platelet Gel following surgery of vulvar cancer shows lesser rate of wound infection, wound necrosis and reduction in rate of fever after surgery.
In case of prolapse reoccurrence; surgery followed by PRF injection show very high success rate.
PRP is being used in the field of aesthetic and plastic surgery. PRP along with or without adipose tissue have been used in following procedures with good success:
As PRP can induce angiogenesis and wound healing it finds great use in gynecological surgeries such as cesarean section, abdominal laprotomy. The wound in PRP treated patients showed reduced redness, edema and faster wound healing, without any adverse effect.