Personalized Embryo Transfer in India At Delhi IVF Centre is a test to identify the window of implantation using ERA test to increase the chances of implantation for an individual with repeated implantation failure.
Personalized embryo transfer during window of implantation is defined as that period when the uterus is receptive for implantation of the free-lying blastocyst. The duration of this process of receptivity is short and thus, results from the arranged sequence of the action of progesterone and estrogen on the endometrium. Implantation starts with an exchange of biochemical signals between trophoblast and the endometrium resulting in attachment of the embryo and decidualization of the uterus. This period is short and for a successful implantation, it is important to know the exact window of implantation for embryo transfer for optimum results. Presently, there is no method of knowing the window of implantation.
Fortunately, Scientist working on this problem has devised a new test for determining the window of implantation. It is called ERA test.
It is a test to determine the window implantation in cases of recurrent or repeated implantation failure when everything else seems to be going well. The ERA test is one of the new developments, which is offering new hope to patients coping with implantation failure. This is a genetic test in which a small sample of endometrial tissue of a woman is taken to verify whether endometrial lining is developed to accept an implanting embryo or not? During this receptive period, proteins are synthesized which make the lining thicker and more suitable for implantation. This usually occurs in 84% women at the expected time.
In 16% of women, this window occurs earlier or might be later than expected. For IVF cycles, it is important to know, that embryo transfer is being done on the correct or incorrect day, where the window is unopened or already got closed, which leads to implantation failure. This test compares the RNA of the receptive period with the non-receptive period. This test is performed with a small endometrial biopsy at a very special time of the cycle to find the RNA profile of the biopsy and compared with the database created during other parts of the IVF cycle.
This test is done only for patients with repeated implantation failure. The time of biopsy is important for this test.
Reasons for Implantation failure?
There can be several factors which can cause implantation failure. Most fall under two categories.
Genetic abnormalities: Most common problem is chromosomal or genetic issues with the embryo, especially old age women using their own eggs. Ageing eggs have much higher chances of chromosomal abnormalities. This describes that why implantation rates reduce as the age of the patient increases. Sometimes, there can be a genetic problem with the sperm. The first line of treatment is to go for PDS (Pre-Implantation Genetic screening). This can improve the implantation rate. Next recommendation is to go for egg donation.
Uterine receptivity problems: If there is no genetic reason for implantation failure, then we should look for uterine receptivity. For this there can be several reasons:
There are many tests to narrow down the problem, and ERA test is one such test
Feeling very happy to have this type of experience. Just because of (IVF) we got twince babies in our life. Thanks you so much Dr. Anoop Gupta and his team. Thanks
First of all thanks to Delhi IVF centre & it’s all staff to bring happiest moment of our life. We feels proud every time we are here. One of the Best IVF centre I have visited ever. Staff is very co-operative. If someone will ask for IVF centre reference then definitely my answer will be Delhi IVF centre.
मेने डॉ. साहब का दिल से धन्यवाद करती हूँ क्यूंकि डॉ. साहब की कोशिश से हमारा सपना पूरा हुआ है | मुझे एक प्यारी सी बेटी की माँ बनने का सपना पूरा हुआ | मै बहुत खुश हूँ
We are so happy for the treatment of Dr. Gupta. We have so many problem in India before I tried many hospital for my wife and i found Delhi IVF. Thank you so much to the all team everyone was friendly with us. All the best for everyone.
I had the opportuned to see you early this year as regards my infertility problem and i am proud to inform you that i was delivered yesterday by C-section of a healthy 3.2 kg baby girl!!!! Many thanks to you, your lovely wife Dr. Alka and your dedicated management team. May God continue to bless you and the works of your hand.
Dear Dr. Anoop Gupta, & Team Greetings !!! Thanks You Once Again for changing our lives with your professional team and today we are living a happy and contented life as we got a gift with your efforts and medicines and our little Baby Girl Aaira was born on 20th February 2017 and our Family in now complete. My another friend Mr. Amin has shown his interest to visit your clinic and he wants to meet you and he has a great desire to have his treatment in your clinic.
Dear Dr. Aastha, Dr. Gupta and Team Hi from italy… I am so happy today Really want to thanks you. You’re so wonderful I had laparoscopy fibroid surgery few months ago. I went to see my doctor here in my country today and all my fibroids are gone. You have a done my surgery so sincerely you’re such a good human being can’t thank you enough I am so happy i had 2 surgeries earlier here in my city and both times I didn’t get better and it was the same. Now I am so happy May God Bless you
After long time my wishes fulfill. Thanks to Delhi IVF & Dr. Anoop Gupta & his team for giving me & my husband such a beautiful gift. Thank you very much.
Feeling very happy to have this type of experience. Just because of (IVF) we got twince babies in our life. Thanks you so much Dr. Anoop Gupta and his team. Thanks
Thank you to Dr. Anoop and his incredible team at Delhi IVF for bringing this bundle of joy to our family after a very long time.